Following are the top leading universities in Ghana:

University of Ghana
- It was founded in 1948 as the University College of the Gold Coast on the recommendation of the Asquith Commission, on Higher Education in the then British colonies.
- The University of Ghana is a member of the International Association of Universities (IAU), the Association of Commonwealth Universities (ACU) and the Association of African Universities (AAU). It is also a member the League of World Universities.
- The University of Ghana is ranked 1st nationally in the Webometrics ranking of Top Colleges and Best Universities of Ghana.

Kwame Nkrumah University of Science and Technology (KNUST)
- Founded in 1952, KNUST has a rich history of its evolvement into a first class university over the years.
- KNUST offers programmes in the fields of Arts, Science, Technology and Business among a host of others.
- KNUST has numerous affiliated institutions which also share in the belief that education holds the ultimate key to national development.

Central University College (CUC)
- The University is organized into the following schools of instruction: the School of Theology and Missions, the Faculty of Arts and Social Sciences, School of Applied Sciences and the School of Business Management and Administration.
- It is the first private tertiary educational institution (University College) to be established in Ghana. The School of Business Management and Administration (SBMA) was established in 1997 as part of a targeted transformational educational initiative of the International Central Gospel Church (ICGC) of Ghana.

Ashesi University College
- It is a private, non-sectarian institution which has gained a reputation for innovation and quality education in Ghana.
- Ashesi is the first university in Ghana to adopt and blend the Liberal Arts method of education with majors in Computer Science, Management Information Systems and Business Administration.

University of Cape Coast
- It was founded in 1962 as a University College and placed in a special relationship with the University of Ghana, Legon. The University of Cape Coast is one of the rare sea front universities in the world.
- The University offers a wide variety of undergraduate and graduate academic programs and majors.

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World University Ranking Tables

America - US News & World Report, The Princeton Review, BusinessWeek
Canada - Maclean's, Gourman Report Ranking of Canadian Universities
UK - Sunday Times, Guardian, Times Good University Guide, Daily Telegraph
World - Shanghai Jiao Tong ARWU Rankings, Webometrics, Newsweek